AM-8553: a novel MDM2 inhibitor with a promising outlook for potential clinical development

J Med Chem. 2012 Jun 14;55(11):4934-5. doi: 10.1021/jm3007068. Epub 2012 May 24.
No abstract available

Publication types

  • Comment

MeSH terms

  • Acetates / chemical synthesis*
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Humans
  • Piperidones / chemical synthesis*
  • Proto-Oncogene Proteins c-mdm2 / metabolism*
  • Tumor Suppressor Protein p53 / metabolism*

Substances

  • 2-(5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-(2-hydroxypentan-3-yl)-3-methyl-2-oxopiperidin-3-yl)acetic acid
  • Acetates
  • Antineoplastic Agents
  • Piperidones
  • Tumor Suppressor Protein p53
  • Proto-Oncogene Proteins c-mdm2